| 14:45 | 1st & 10 | OWN 31 | Malik Williams run for 2 yds to the Lvile 33 | +2 | -0.57 |
| 14:13 | 2nd & 8 | OWN 33 | Lamar Jackson pass incomplete to Jaylen Smith | 0 | -0.65 |
| 14:13 | 3rd & 8 | OWN 33 | Timeout LOUISVILLE, clock 14:13 | ||
| 14:04 | 3rd & 8 | OWN 33 | Lamar Jackson run for 7 yds to the Lvile 40 | +7 | 0.28 |
| 13:40 | 4th & 1 | OWN 40 | Mason King punt for 39 yds, punt out-of-bounds at the Clem 21 |
| 13:28 | 1st & 10 | OWN 21 | C.J. Fuller run for 4 yds to the Clem 25 | +4 | -0.09 |
| 13:15 | 2nd & 6 | OWN 25 | Kelly Bryant pass complete to Ray-Ray McCloud for 5 yds to the Clem 30 | +5 | 0.08 |
| 12:41 | 3rd & 1 | OWN 30 | C.J. Fuller run for 3 yds to the Clem 33 for a 1ST down | +3 | 0.91 |
| 12:11 | 1st & 10 | OWN 33 | Kelly Bryant pass complete to Ray-Ray McCloud for 7 yds to the Clem 40 | +7 | 0.70 |
| 11:46 | 2nd & 3 | OWN 40 | Kelly Bryant pass complete to Hunter Renfrow for 40 yds to the Lvile 20 for a 1ST down | +40 | 2.11 |
| 11:31 | 1st & 10 | OPP 20 | C.J. Fuller run for 5 yds to the Lvile 15 | +5 | 0.07 |
| 11:05 | 2nd & 5 | OPP 15 | Kelly Bryant pass complete to Ray-Ray McCloud for 1 yd to the Lvile 14 | +1 | -0.32 |
| 10:30 | 3rd & 4 | OPP 14 | Kelly Bryant run for 3 yds to the Lvile 11 | +3 | -0.14 |
| 10:11 | 4th & 1 | OPP 11 | C.J. Fuller run for 3 yds to the Lvile 8 for a 1ST down | +3 | 0.68 |
| 9:45 | 1st & 8 | OPP 8 | Kelly Bryant run for 8 yds for a TD, (Greg Huegel KICK) | +8 | 2.32 |
| 9:35 | 1st & 10 | OWN 25 | Reggie Bonnafon run for 2 yds to the Lvile 27 | +2 | -0.45 |
| 9:07 | 2nd & 8 | OWN 27 | Lamar Jackson pass incomplete to Jaylen Smith | 0 | -0.48 |
| 9:02 | 3rd & 8 | OWN 27 | Lamar Jackson pass incomplete to Dez Fitzpatrick | 0 | -0.22 |
| 8:53 | 4th & 8 | OWN 27 | Mason King punt for 50 yds, fair catch by Ray-Ray McCloud at the Clem 23 |
| 8:42 | 1st & 10 | OWN 23 | Kelly Bryant run for 5 yds to the Clem 28 | +5 | 0.09 |
| 8:17 | 2nd & 5 | OWN 28 | Kelly Bryant pass incomplete to Diondre Overton | 0 | -0.69 |
| 8:06 | 3rd & 5 | OWN 28 | Kelly Bryant pass complete to Trevion Thompson for 16 yds to the Clem 44 for a 1ST down | +16 | 2.44 |
| 7:40 | 1st & 10 | OWN 44 | C.J. Fuller run for 1 yd to the Clem 45 | +1 | -0.93 |
| 7:11 | 2nd & 9 | OWN 45 | Kelly Bryant pass incomplete to C.J. Fuller | 0 | -0.96 |
| 6:58 | 3rd & 9 | OWN 45 | Kelly Bryant sacked by Jonathan Greenard for a loss of 14 yards to the Clem 31 | -14 | -1.10 |
| 6:20 | 4th & 23 | OWN 31 | Will Spiers punt for 64 yds, punt out-of-bounds at the Lvile 5 |
| 6:15 | 1st & 10 | OWN 5 | Lamar Jackson pass incomplete to Micky Crum | 0 | -0.28 |
| 6:05 | 2nd & 10 | OWN 5 | Lamar Jackson run for 15 yds to the Lvile 20 for a 1ST down | +15 | 0.81 |
| 5:28 | 1st & 10 | OWN 20 | Lamar Jackson run for 30 yds to the 50 yard line for a 1ST down | +30 | 2.54 |
| 5:10 | 1st & 10 | 50 | Lamar Jackson pass complete to Malik Williams for 19 yds to the Clem 31 for a 1ST down | +19 | 1.00 |
| 4:43 | 1st & 10 | OPP 21 | Lamar Jackson run for 10 yds to the Clem 21 for a 1ST down CLEMSON Penalty, Personal Foul (Tanner Muse) to the Clem 11 for a 1ST down | +20 | 1.69 |
| 4:22 | 1st & 10 | OPP 11 | Lamar Jackson pass complete to Charles Standberry for 11 yds for a TD, (Blanton Creque KICK) | +11 | 2.52 |
| 4:04 | 1st & 10 | OWN 9 | Tavien Feaster run for a loss of 5 yards to the Clem 4 | -5 | -0.49 |
| 3:32 | 2nd & 15 | OWN 4 | Tavien Feaster run for 9 yds to the Clem 13 | +9 | 0.13 |
| 2:56 | 3rd & 6 | OWN 13 | Kelly Bryant pass complete to Deon Cain for 11 yds to the Clem 24 for a 1ST down | +11 | 1.03 |
| 2:34 | 1st & 10 | OWN 24 | Kelly Bryant pass incomplete to Deon Cain | 0 | -0.67 |
| 2:27 | 2nd & 10 | OWN 24 | Tavien Feaster run for 12 yds to the Clem 36 for a 1ST down | +12 | 1.67 |
| 2:02 | 1st & 10 | OWN 36 | Kelly Bryant pass complete to Ray-Ray McCloud for 4 yds to the Clem 40 | +4 | -0.16 |
| 1:31 | 2nd & 6 | OWN 40 | Kelly Bryant pass incomplete to Deon Cain, broken up by Chucky Williams | 0 | -0.99 |
| 1:25 | 3rd & 6 | OWN 40 | Kelly Bryant pass incomplete to Diondre Overton | 0 | -0.58 |
| 1:14 | 4th & 6 | OWN 40 | Will Spiers punt for 58 yds , Jaylen Smith returns for 3 yds to the Lvile 5 |
| 1:07 | 1st & 10 | OWN 5 | Lamar Jackson pass complete to Jaylen Smith for 15 yds to the Lvile 20 for a 1ST down | +15 | 0.53 |
| 0:46 | 1st & 10 | OWN 20 | Lamar Jackson pass incomplete to Jaylen Smith | 0 | -0.56 |
| 0:37 | 2nd & 10 | OWN 20 | Malik Williams run for 6 yds to the Lvile 26 | +6 | 0.14 |
| 0:00 | 3rd & 4 | OWN 26 | Lamar Jackson sacked by Christian Wilkins for a loss of 9 yards to the Lvile 17 | -9 | -0.55 |
| 0:00 | OWN 0 | End of 1st Quarter | |||
| 14:50 | 4th & 13 | OWN 17 | Mason King punt for 44 yds , Ray-Ray McCloud returns for 1 yd to the Clem 40 |
| 14:41 | 1st & 10 | OWN 40 | Kelly Bryant run for 11 yds to the Lvile 49 for a 1ST down | +11 | 0.99 |
| 14:25 | 1st & 10 | OPP 49 | Kelly Bryant pass complete to Tee Higgins for 8 yds to the Lvile 41 | +8 | 0.82 |
| 13:53 | 2nd & 2 | OPP 41 | Adam Choice run for a loss of 1 yard to the Lvile 42 | -1 | -1.35 |
| 13:19 | 3rd & 3 | OPP 42 | Kelly Bryant pass complete to Hunter Renfrow for 12 yds to the Lvile 30 for a 1ST down | +12 | 1.48 |
| 12:55 | 1st & 10 | OPP 30 | Kelly Bryant sacked by James Hearns for a loss of 6 yards to the Lvile 36 | -6 | -1.57 |
| 12:18 | 2nd & 16 | OPP 36 | Kelly Bryant pass complete to Tavien Feaster for 7 yds to the Lvile 29 | +7 | 0.43 |
| 11:57 | 3rd & 9 | OPP 29 | Kelly Bryant pass incomplete to Ray-Ray McCloud, broken up by Jonathan Greenard | 0 | -0.96 |
| 11:57 | 4th & 9 | OPP 29 | LOUISVILLE Penalty, Defensive Offside (5 Yards) to the Lvile 24 | +5 | |
| 11:52 | 4th & 4 | OPP 24 | Greg Huegel 42 yd FG MISSED |
| 11:45 | 1st & 10 | OWN 25 | Lamar Jackson pass complete to Seth Dawkins for 2 yds to the Lvile 27 | +2 | -0.45 |
| 11:09 | 2nd & 8 | OWN 27 | Lamar Jackson run for 2 yds to the Lvile 29 | +2 | -0.31 |
| 10:35 | 3rd & 6 | OWN 29 | Lamar Jackson pass incomplete | 0 | -0.31 |
| 10:22 | 4th & 6 | OWN 29 | Mason King punt for 41 yds , Ray-Ray McCloud returns for 15 yds to the Clem 45 |
| 10:18 | 1st & 10 | OWN 45 | Kelly Bryant pass incomplete to Ray-Ray McCloud, broken up by Khane Pass | 0 | -1.16 |
| 10:10 | 2nd & 10 | OWN 45 | Kelly Bryant pass complete to Milan Richard for 11 yds to the Lvile 44 for a 1ST down | +11 | 2.03 |
| 9:46 | 1st & 10 | OPP 44 | Kelly Bryant pass complete to Ray-Ray McCloud for 8 yds to the Lvile 36 | +8 | 0.71 |
| 9:15 | 2nd & 2 | OPP 36 | Kelly Bryant run for 14 yds to the Lvile 22 for a 1ST down | +14 | 0.05 |
| 8:46 | 1st & 10 | OPP 22 | C.J. Fuller run for 7 yds to the Lvile 15 | +7 | 0.32 |
| 8:15 | 2nd & 3 | OPP 15 | Kelly Bryant run for 1 yd to the Lvile 14 | +1 | -0.38 |
| 7:38 | 3rd & 2 | OPP 14 | Kelly Bryant run for no gain to the Lvile 14 | 0 | -0.46 |
| 6:57 | 4th & 2 | OPP 14 | Greg Huegel 31 yd FG GOOD | -0.83 |
| 6:44 | 1st & 10 | OWN 21 | Lamar Jackson pass complete to Seth Dawkins for 12 yds to the Lvile 33 for a 1ST down | +12 | 0.90 |
| 6:21 | 1st & 10 | OWN 35 | Lamar Jackson pass complete to Seth Dawkins for 2 yds to the Lvile 35 LOUISVILLE Penalty, Offensive Holding (Dez Fitzpatrick) to the Lvile 25 | -8 | -1.85 |
| 5:58 | 1st & 18 | OWN 25 | Lamar Jackson pass incomplete to Jaylen Smith | 0 | -0.33 |
| 5:50 | 2nd & 18 | OWN 25 | Lamar Jackson pass incomplete to Seth Dawkins | 0 | -0.15 |
| 5:44 | 3rd & 18 | OWN 25 | Lamar Jackson pass incomplete to Reggie Bonnafon | 0 | -0.07 |
| 5:31 | 4th & 18 | OWN 25 | Mason King punt for 58 yds , Ray-Ray McCloud returns for a loss of 7 yards to the Clem 10 |
| 5:20 | 1st & 10 | OWN 10 | Tavien Feaster run for 4 yds to the Clem 14 | +4 | -0.05 |
| 4:53 | 2nd & 6 | OWN 14 | Kelly Bryant pass complete to Deon Cain for 5 yds to the Clem 19 | +5 | 0.07 |
| 4:25 | 3rd & 1 | OWN 19 | Kelly Bryant run for 2 yds to the Clem 21 for a 1ST down | +2 | 0.44 |
| 4:06 | 1st & 10 | OWN 21 | Kelly Bryant pass complete to Ray-Ray McCloud for 79 yds for a TD, (Greg Huegel PAT BLOCKED) | +79 | 6.33 |
| 3:59 | 1st & 10 | OWN 25 | Malik Williams run for 14 yds to the Lvile 39 for a 1ST down | +14 | 1.22 |
| 3:33 | 1st & 10 | OWN 39 | Lamar Jackson pass incomplete to Jaylen Smith | 0 | -1.11 |
| 3:30 | 2nd & 10 | OWN 39 | Lamar Jackson pass incomplete to Traveon Samuel | 0 | -0.73 |
| 3:25 | 3rd & 10 | OWN 39 | Lamar Jackson pass incomplete to Dez Fitzpatrick | 0 | -0.39 |
| 3:17 | 4th & 10 | OWN 39 | Mason King punt for 41 yds, fair catch by Hunter Renfrow at the Clem 20 |
| 3:12 | 1st & 10 | OWN 24 | Kelly Bryant run for 4 yds to the Clem 24 CLEMSON Penalty, Offensive Holding (John Simpson) to the Clem 14 | -6 | -1.06 |
| 2:45 | 1st & 16 | OWN 14 | Kelly Bryant pass complete to Deon Cain for 3 yds to the Clem 17 | +3 | -0.09 |
| 2:15 | 2nd & 13 | OWN 17 | Adam Choice run for 3 yds to the Clem 20 | +3 | -0.07 |
| 1:17 | 1st & 10 | OWN 31 | Bryant, Kelly pass incomplete to Cain, Deon, PENALTY LOUISVILLE offside 5 yards to the CLEMSON36, NO PLAY. | +5 | |
| 1:13 | 1st & 5 | OWN 36 | Kelly Bryant pass incomplete to Deon Cain | 0 | -1.43 |
| 1:06 | 2nd & 5 | OWN 36 | Tavien Feaster run for 16 yds to the Lvile 48 for a 1ST down | +16 | 1.82 |
| 0:55 | 1st & 10 | OPP 48 | Kelly Bryant pass complete to Deon Cain for 10 yds to the Lvile 38 for a 1ST down | +10 | 0.59 |
| 0:43 | 1st & 10 | OPP 38 | Kelly Bryant run for 7 yds to the Lvile 31 | +7 | 0.42 |
| 0:43 | 2nd & 3 | OPP 31 | Timeout CLEMSON, clock 00:43 | ||
| 0:38 | 2nd & 3 | OPP 31 | Kelly Bryant pass incomplete to Ray-Ray McCloud, broken up by Trumaine Washington | 0 | -0.77 |
| 0:34 | 3rd & 3 | OPP 31 | Kelly Bryant pass incomplete to Deon Cain, broken up by Chucky Williams | 0 | -0.92 |
| 0:28 | 4th & 3 | OPP 31 | Greg Huegel 49 yd FG GOOD | 0.37 |
| 0:16 | 1st & 10 | OWN 20 | Lamar Jackson pass complete to Charles Standberry for 11 yds to the Lvile 31 for a 1ST down | +11 | 0.78 |
| 0:10 | 1st & 10 | OWN 31 | Lamar Jackson pass complete to Jaylen Smith for 11 yds to the Lvile 42 for a 1ST down | +11 | 1.05 |
| 0:00 | 1st & 10 | OWN 42 | Lamar Jackson sacked by Dexter Lawrence for a loss of 8 yards to the Lvile 34 | -8 | -2.32 |
| 0:00 | OWN 0 | End of 2nd Quarter |
| 14:53 | 1st & 10 | OWN 25 | C.J. Fuller run for 5 yds to the Clem 30 | +5 | 0.09 |
| 14:24 | 2nd & 5 | OWN 30 | Kelly Bryant pass complete to Diondre Overton for 15 yds to the Clem 45 for a 1ST down | +15 | 1.71 |
| 13:57 | 1st & 10 | OWN 45 | Kelly Bryant pass complete to C.J. Fuller for 11 yds to the Lvile 44 for a 1ST down | +11 | 0.86 |
| 13:32 | 1st & 10 | OPP 44 | Tavien Feaster run for 10 yds to the Lvile 34 for a 1ST down | +10 | 0.48 |
| 13:10 | 1st & 10 | OPP 34 | Kelly Bryant run for 1 yd to the Lvile 33 | +1 | -0.50 |
| 12:45 | 2nd & 9 | OPP 33 | Kelly Bryant pass complete to Hunter Renfrow for 3 yds to the Lvile 30 | +3 | -0.27 |
| 12:01 | 3rd & 6 | OPP 30 | Kelly Bryant sacked by London Iakopo for a loss of 9 yards to the Lvile 39 | -9 | -2.69 |
| 11:29 | 4th & 15 | OPP 39 | Will Spiers punt for 39 yds for a touchback |
| 11:19 | 1st & 10 | OWN 20 | Lamar Jackson run for a loss of 1 yard to the Lvile 19 | -1 | -0.63 |
| 10:50 | 2nd & 11 | OWN 19 | Lamar Jackson pass complete to Malik Williams for 6 yds to the Lvile 25 | +6 | 0.11 |
| 10:22 | 3rd & 5 | OWN 25 | Lamar Jackson pass complete to Jaylen Smith for 12 yds to the Lvile 37 for a 1ST down | +12 | 1.86 |
| 9:53 | 1st & 10 | OWN 37 | LOUISVILLE Penalty, Personal Foul (Charles Standberry) to the Lvile 22 | -15 | |
| 9:27 | 1st & 25 | OWN 22 | Lamar Jackson pass complete to Seth Dawkins for 12 yds to the Lvile 34 | +12 | 0.58 |
| 8:57 | 2nd & 13 | OWN 34 | Lamar Jackson pass intercepted for a TD Dorian O'Daniel return for 44 yds for a TD, (Greg Huegel KICK) | -7.42 |
| 8:53 | 1st & 10 | OWN 25 | Lamar Jackson pass incomplete to Jaylen Smith, broken up by Kendall Joseph | 0 | -0.70 |
| 8:44 | 2nd & 10 | OWN 25 | Reggie Bonnafon run for 7 yds to the Lvile 32 | +7 | 0.31 |
| 8:15 | 3rd & 3 | OWN 32 | Lamar Jackson run for no gain to the Lvile 32 | 0 | -0.51 |
| 7:30 | 4th & 3 | OWN 32 | Mason King punt for 34 yds, downed at the Clem 34 |
| 7:18 | 1st & 10 | OWN 34 | Tavien Feaster run for 4 yds to the Clem 38 | +4 | -0.16 |
| 6:55 | 2nd & 6 | OWN 38 | Tavien Feaster run for 7 yds to the Clem 45 for a 1ST down | +7 | 1.22 |
| 6:19 | 1st & 10 | OWN 45 | Kelly Bryant sacked by James Hearns for a loss of 6 yards to the Clem 39 | -6 | -2.25 |
| 5:44 | 2nd & 16 | OWN 39 | Kelly Bryant run for 3 yds to the Clem 42 | +3 | -0.21 |
| 5:10 | 3rd & 13 | OWN 42 | Kelly Bryant pass complete to Hunter Renfrow for 16 yds to the Lvile 42 for a 1ST down | +16 | 3.44 |
| 4:43 | 1st & 10 | OPP 42 | Tavien Feaster run for 26 yds to the Lvile 16 for a 1ST down | +26 | 0.73 |
| 4:14 | 1st & 10 | OPP 16 | Tavien Feaster run for 9 yds to the Lvile 7 | +9 | 0.62 |
| 3:44 | 2nd & 1 | OPP 7 | C.J. Fuller run for 6 yds to the Lvile 1 for a 1ST down | +6 | 1.01 |
| 3:23 | 1st & 1 | OPP 1 | C.J. Fuller run for no gain to the Lvile 1 | 0 | -0.96 |
| 2:52 | 2nd & 1 | OPP 1 | C.J. Fuller run for no gain to the Lvile 1 | 0 | -0.55 |
| 2:16 | 3rd & 1 | OPP 1 | Kelly Bryant run for 1 yd for a TD, (Greg Huegel KICK) | +1 | 2.45 |
| 2:01 | 1st & 10 | OWN 25 | Lamar Jackson run for 15 yds to the Lvile 40 for a 1ST down | +15 | 1.32 |
| 1:35 | 1st & 10 | OWN 40 | Lamar Jackson run for 1 yd to the Lvile 41 | +1 | -0.91 |
| 1:03 | 2nd & 9 | OWN 41 | Reggie Bonnafon run for 5 yds to the Lvile 46 | +5 | 0.08 |
| 0:39 | 3rd & 4 | OWN 46 | Reggie Bonnafon run for 3 yds to the Lvile 49 | +3 | -0.36 |
| 0:00 | 4th & 1 | OWN 49 | Lamar Jackson pass complete to Jaylen Smith for 5 yds to the Clem 46 for a 1ST down | +5 | 2.41 |
| 0:00 | OWN 0 | End of 3rd Quarter | |||
| 14:49 | 1st & 10 | OPP 46 | Lamar Jackson pass complete to Charles Standberry for 3 yds to the Clem 43 | +3 | -0.34 |
| 14:24 | 2nd & 7 | OPP 43 | Malik Williams run for 5 yds to the Clem 38 | +5 | 0.09 |
| 14:00 | 3rd & 2 | OPP 38 | Lamar Jackson run for 2 yds to the Clem 36 for a 1ST down | +2 | 0.78 |
| 13:45 | 1st & 10 | OPP 36 | Lamar Jackson pass complete to Jaylen Smith for 36 yds for a TD, (Blanton Creque KICK) | +36 | 3.01 |
| 13:32 | 1st & 10 | OWN 21 | Kelly Bryant run for 1 yd to the Clem 22 | +1 | -0.49 |
| 13:01 | 2nd & 9 | OWN 22 | Adam Choice run for 6 yds to the Clem 28 | +6 | 0.17 |
| 12:26 | 3rd & 3 | OWN 28 | Kelly Bryant pass complete to Diondre Overton for 33 yds to the Lvile 39 for a 1ST down | +33 | 3.51 |
| 11:56 | 1st & 10 | OPP 39 | Adam Choice run for 39 yds for a TD, (Greg Huegel KICK) | +39 | 3.14 |
| 11:43 | 1st & 10 | OWN 15 | Malik Williams run for 12 yds to the Lvile 27 for a 1ST down | +12 | 0.69 |
| 11:19 | 1st & 10 | OWN 27 | Lamar Jackson sacked by Albert Huggins for a loss of 2 yards to the Lvile 25 | -2 | -0.97 |
| 10:50 | 2nd & 12 | OWN 25 | Lamar Jackson pass complete to Micky Crum for 2 yds to the Lvile 27 | +2 | -0.19 |
| 10:19 | 3rd & 10 | OWN 27 | Lamar Jackson pass complete to Traveon Samuel for 22 yds to the Lvile 49 for a 1ST down | +22 | 3.16 |
| 9:53 | 1st & 10 | OWN 49 | Lamar Jackson pass incomplete to Seth Dawkins | 0 | -1.13 |
| 9:42 | 2nd & 10 | OWN 49 | Malik Williams run for a loss of 4 yards to the Lvile 45 | -4 | -1.60 |
| 9:06 | 3rd & 14 | OWN 45 | Lamar Jackson pass complete to Malik Williams for 11 yds to the Clem 44 | +11 | 1.04 |
| 8:39 | 4th & 3 | OPP 44 | Timeout LOUISVILLE, clock 08:39 | ||
| 8:39 | 4th & 3 | OPP 44 | Timeout CLEMSON, clock 08:39 | ||
| 8:30 | 4th & 3 | OPP 44 | Lamar Jackson pass complete to Dez Fitzpatrick for 30 yds to the Clem 14 for a 1ST down | +30 | 3.06 |
| 8:09 | 1st & 10 | OPP 14 | Lamar Jackson pass incomplete to Jaylen Smith, broken up by K'Von Wallace | 0 | -0.31 |
| 8:03 | 2nd & 10 | OPP 14 | Lamar Jackson run for 6 yds to the Clem 8 | +6 | 0.11 |
| 7:37 | 3rd & 4 | OPP 8 | Lamar Jackson pass complete to Dez Fitzpatrick for 8 yds for a TD, (Blanton Creque KICK) | +8 | 2.75 |
| 7:25 | 1st & 10 | OWN 25 | Travis Etienne run for 4 yds to the Clem 29 | +4 | -0.11 |
| 6:50 | 2nd & 6 | OWN 29 | CLEMSON Penalty, False Start (Sean Pollard) to the Clem 24 | -5 | |
| 6:27 | 2nd & 11 | OWN 24 | CLEMSON Penalty, False Start (Taylor Hearn) to the Clem 19 | -5 | |
| 6:13 | 2nd & 16 | OWN 19 | Travis Etienne run for 81 yds for a TD, (Greg Huegel KICK) | +81 | 7.19 |
| 6:01 | 1st & 10 | OWN 22 | Lamar Jackson pass incomplete to Jaylen Smith | 0 | -0.61 |
| 5:56 | 2nd & 10 | OWN 22 | Lamar Jackson pass incomplete to Malik Williams | 0 | -0.29 |
| 5:44 | 3rd & 10 | OWN 22 | Lamar Jackson sacked by Sterling Johnson for a loss of 3 yards to the Lvile 19 | -3 | -0.17 |
| 4:57 | 4th & 13 | OWN 19 | Mason King punt for 43 yds, downed at the Clem 38 |
| 4:44 | 1st & 10 | OWN 38 | Travis Etienne run for 2 yds to the Clem 40 | +2 | -0.67 |
| 4:14 | 2nd & 8 | OWN 40 | Travis Etienne run for 5 yds to the Clem 45 | +5 | 0.08 |
| 3:31 | 3rd & 3 | OWN 45 | Hunter Johnson pass complete to Will Swinney for no gain to the Clem 45 | 0 | -0.91 |
| 2:59 | 4th & 3 | OWN 45 | Timeout CLEMSON, clock 02:59 | ||
| 2:47 | 4th & 3 | OWN 45 | Will Spiers punt for 46 yds, downed at the Lvile 9 |
| 2:43 | 1st & 10 | OWN 9 | Lamar Jackson pass complete to Charles Standberry for 9 yds to the Lvile 18 | +9 | 0.80 |
| 2:17 | 2nd & 1 | OWN 18 | Lamar Jackson run for no gain to the Lvile 18 | 0 | -0.78 |
| 1:50 | 3rd & 1 | OWN 18 | Lamar Jackson pass complete to Traveon Samuel for 78 yds to the Clem 4 for a 1ST down | +78 | 5.11 |
| 1:29 | 1st & 4 | OPP 4 | Lamar Jackson pass incomplete to Dez Fitzpatrick | 0 | -0.65 |
| 1:20 | 2nd & 4 | OPP 4 | Lamar Jackson run for a loss of 1 yard to the Clem 5 | -1 | -0.43 |
| 1:20 | 3rd & goal | OPP 5 | Timeout LOUISVILLE, clock 01:20 | ||
| 1:16 | 3rd & 5 | OPP 5 | Lamar Jackson pass incomplete to Seth Dawkins, broken up by Denzel Johnson | 0 | -0.29 |
| 1:11 | 4th & 5 | OPP 5 | Lamar Jackson pass incomplete to Seth Dawkins | 0 | -3.95 |
| 1:03 | 1st & 10 | OWN 5 | Travis Etienne run for 4 yds to the Clem 9 | +4 | -0.03 |
| 0:00 | 2nd & 6 | OWN 9 | Travis Etienne run for 2 yds to the Clem 11 | +2 | -0.17 |
| 0:00 | OPP 0 | End of 4th Quarter |
| 4 | sacks | 4 |
| 8 | plays for loss | 7 |
| 1 | takeaways | 0 |
| 5 | three-and-outs forced | 1 |
| 11 | explosive plays allowed | 11 |
| 6.28 | yards allowed / play | 7.40 |
| 3 of 14 | scoring drives allowed | 7 of 13 |
| Isaiah Simmons | 8 (6) | |
| Dorian O'Daniel | 6 (3) | 1 TFL · 1 INT |
| Mark Fields | 5 (5) | |
| Trayvon Mullen | 5 (3) | |
| Van Smith | 4 (3) | |
| Clelin Ferrell | 3 (2) | |
| Nolan Turner | 2 (2) | 1 sk · 1 TFL |
| Dexter Lawrence | 2 (1) | 1 sk · 1 TFL |
| Stacy Thomas | 10 (5) | |
| Zykiesis Cannon | 9 (6) | |
| James Hearns | 8 (6) | 2 sk · 2 TFL |
| Ronald Walker | 7 (6) | |
| Khane Pass | 5 (3) | 1 TFL · 1 PD |
| Chucky Williams | 5 (5) | 2 PD |
| Trevon Young | 5 (3) | |
| Dee Smith | 5 (3) |
| 2 of 3 | field goals | — |
| 4 | punts | 8 |
| 51.8 | punt average | 43.8 |
| 0 | punts inside the 20 | 0 |
| 39 | return yards | 108 |
| own 26 | average drive start | own 17 |
| K | Greg Huegel | 2/3 FG · long 49 · 5/6 XP |
| P | Will Spiers | 4 punts · 51.8 avg |
| KR | Travis Etienne | 2 ret · 30 yds · long 21 |
| PR | Ray-Ray McCloud | 3 ret · 9 yds · long 15 |
| K | Blanton Creque | 3/3 XP |
| P | Mason King | 8 punts · 43.8 avg |
| KR | Seth Dawkins | 5 ret · 105 yds · long 31 |
| PR | Jaylen Smith | 1 ret · 3 yds · long 3 |
| 80 | plays | 69 |
| 592 | yards | 433 |
| 13 | drives | 14 |
| 46% | success rate | 33% |
| 28.09 | total PPA | 6.72 |
| Q1 | Kelly Bryant run for 8 yds for a TD, (Greg Huegel KICK) | 7–0 |
| Q1 | Lamar Jackson pass complete to Charles Standberry for 11 yds for a TD, (Blanton Creque KICK) | 7–7 |
| Q2 | Greg Huegel 31 yd FG GOOD | 10–7 |
| Q2 | Kelly Bryant pass complete to Ray-Ray McCloud for 79 yds for a TD, (Greg Huegel PAT BLOCKED) | 16–7 |
| Q2 | Greg Huegel 49 yd FG GOOD | 19–7 |
| Q3 | Lamar Jackson pass intercepted for a TD Dorian O'Daniel return for 44 yds for a TD, (Gregβ¦ | 7–26 |
| Q3 | Kelly Bryant run for 1 yd for a TD, (Greg Huegel KICK) | 33–7 |
| Q4 | Lamar Jackson pass complete to Jaylen Smith for 36 yds for a TD, (Blanton Creque KICK) | 14–33 |
| Q4 | Adam Choice run for 39 yds for a TD, (Greg Huegel KICK) | 40–14 |
| Q4 | Lamar Jackson pass complete to Dez Fitzpatrick for 8 yds for a TD, (Blanton Creque KICK) | 21–40 |
| Q4 | Travis Etienne run for 81 yds for a TD, (Greg Huegel KICK) | 47–21 |
| Q4 | Travis Etienne run for 81 yds for a TD, (Greg Huegel KICK) | 7.19 |
| Q2 | Kelly Bryant pass complete to Ray-Ray McCloud for 79 yds for a TD, (Greg Huegel PAT⦠| 6.33 |
| Q4 | Lamar Jackson pass complete to Traveon Samuel for 78 yds to the Clem 4 for a 1ST down | 5.11 |
| Q4 | Kelly Bryant pass complete to Diondre Overton for 33 yds to the Lvile 39 for a 1ST down | 3.51 |
| Q3 | Kelly Bryant pass complete to Hunter Renfrow for 16 yds to the Lvile 42 for a 1ST down | 3.44 |
| Q4 | Lamar Jackson pass complete to Traveon Samuel for 22 yds to the Lvile 49 for a 1ST down | 3.16 |
| 2025 | Clemson 20 – 19 Louisville |
| 2024 | Louisville 33 – 21 Clemson |
| 2022 | Louisville 16 – 31 Clemson |
| 2021 | Clemson 30 – 24 Louisville |
| 2019 | Clemson 45 – 10 Louisville |
| 2018 | Louisville 16 – 77 Clemson |
| 2016 | Louisville 36 – 42 Clemson |
| 2015 | Clemson 20 – 17 Louisville |