| 15:00 | 1st & 10 | OWN 23 | LOUISVILLE Penalty, False Start (-5 Yards) to the Lvile 18 | -5 | |
| 15:00 | 1st & 15 | OWN 18 | LOUISVILLE Penalty, False Start (-5 Yards) to the Lvile 13 | -5 | |
| 14:30 | 1st & 20 | OWN 13 | Brandon Radcliff run for 5 yds to the Lvile 18 | +5 | 0.01 |
| 14:18 | 2nd & 15 | OWN 18 | Lamar Jackson pass incomplete to Jamari Staples | 0 | -0.13 |
| 14:13 | 3rd & 15 | OWN 18 | Lamar Jackson pass incomplete to L.J. Scott | 0 | -0.06 |
| 14:07 | 4th & 15 | OWN 18 | Mason King punt for 41 yds, fair catch by Ray-Ray McCloud at the Clem 41 |
| 13:50 | 1st & 10 | OWN 41 | Wayne Gallman run for 12 yds to the Lvile 47 for a 1ST down | +12 | 1.05 |
| 13:35 | 1st & 10 | OPP 47 | Deshaun Watson pass incomplete | 0 | -1.05 |
| 13:22 | 2nd & 10 | OPP 47 | Deshaun Watson run for 5 yds to the Lvile 42 | +5 | 0.07 |
| 13:02 | 3rd & 5 | OPP 42 | Deshaun Watson pass incomplete to Jordan Leggett | 0 | -1.08 |
| 12:53 | 4th & 5 | OPP 42 | Andy Teasdall punt for 41 yds, downed at the Lvile 1 |
| 12:50 | 1st & 10 | OWN 1 | Lamar Jackson pass incomplete | 0 | -0.24 |
| 12:43 | 2nd & 10 | OWN 1 | Jeremy Smith run for 34 yds to the Lvile 35 for a 1ST down | +34 | 1.99 |
| 12:15 | 1st & 10 | OWN 35 | Lamar Jackson run for a loss of 7 yards to the Lvile 28 | -7 | -1.79 |
| 11:39 | 2nd & 17 | OWN 28 | Jeremy Smith run for no gain to the Lvile 28 | 0 | -0.21 |
| 11:15 | 3rd & 17 | OWN 28 | LOUISVILLE Penalty, False Start (-5 Yards) to the Lvile 23 | -5 | |
| 10:40 | 3rd & 22 | OWN 23 | Lamar Jackson sacked by Ben Boulware for a loss of 4 yards to the Lvile 19 | -4 | -0.06 |
| 9:59 | 4th & 26 | OWN 19 | Mason King punt for 60 yds , Ray-Ray McCloud returns for 1 yd to the Clem 20 CLEMSON Penalty, Illegal Block (12 Yards) to the Clem 10 |
| 9:45 | 1st & 10 | OWN 10 | Deshaun Watson run for 7 yds to the Clem 17 | +7 | 0.38 |
| 9:26 | 2nd & 3 | OWN 17 | Deshaun Watson pass incomplete to Mike Williams | 0 | -0.56 |
| 9:20 | 3rd & 3 | OWN 17 | Deshaun Watson run for 6 yds to the Clem 23 for a 1ST down | +6 | 0.77 |
| 8:48 | 1st & 10 | OWN 23 | Wayne Gallman run for 6 yds to the Clem 29 | +6 | 0.32 |
| 8:29 | 2nd & 4 | OWN 29 | Wayne Gallman run for 8 yds to the Clem 37 for a 1ST down | +8 | 0.84 |
| 7:58 | 1st & 10 | OWN 37 | Deshaun Watson pass complete to Ray-Ray McCloud for 1 yd to the Clem 38 | +1 | -0.87 |
| 7:35 | 2nd & 9 | OWN 38 | Deshaun Watson run for 2 yds to the Clem 40 | +2 | -0.48 |
| 6:55 | 3rd & 7 | OWN 40 | Deshaun Watson pass incomplete to Mike Williams | 0 | -0.53 |
| 6:46 | 4th & 7 | OWN 40 | Andy Teasdall punt for 45 yds, fair catch by Jaire Alexander at the Lvile 15 |
| 6:40 | 1st & 10 | OWN 15 | Lamar Jackson pass incomplete | 0 | -0.44 |
| 6:28 | 2nd & 10 | OWN 15 | Lamar Jackson run for 4 yds to the Lvile 19 | +4 | -0.03 |
| 5:30 | 3rd & 6 | OWN 19 | Lamar Jackson sacked by Clelin Ferrell for a loss of 2 yards to the Lvile 17 | -2 | -0.22 |
| 5:08 | 4th & 8 | OWN 17 | Mason King punt for 52 yds, fair catch by Ray-Ray McCloud at the Clem 31 |
| 5:02 | 1st & 10 | OWN 31 | Deshaun Watson pass incomplete to Mike Williams | 0 | -0.89 |
| 4:50 | 2nd & 10 | OWN 31 | Deshaun Watson run for 4 yds to the Clem 35 | +4 | -0.09 |
| 4:13 | 3rd & 6 | OWN 35 | Deshaun Watson run for 3 yds to the Clem 38 | +3 | -0.19 |
| 3:27 | 4th & 3 | OWN 38 | Andy Teasdall punt for 44 yds, downed at the Lvile 18 |
| 3:18 | 1st & 10 | OWN 18 | Brandon Radcliff run for 4 yds to the Lvile 22 | +4 | -0.08 |
| 2:45 | 2nd & 6 | OWN 22 | Lamar Jackson pass complete to Jamari Staples for 8 yds to the Lvile 30 for a 1ST down | +8 | 0.87 |
| 2:26 | 1st & 10 | OWN 30 | Lamar Jackson pass complete to Jamari Staples for 5 yds to the Lvile 35 | +5 | 0.10 |
| 1:55 | 2nd & 5 | OWN 35 | Brandon Radcliff run for 12 yds to the Lvile 47 for a 1ST down | +12 | 1.49 |
| 1:33 | 1st & 10 | OWN 47 | Lamar Jackson run for 16 yds to the Clem 37 for a 1ST down | +16 | 1.04 |
| 1:05 | 1st & 10 | OPP 37 | Brandon Radcliff run for 5 yds to the Clem 32 | +5 | 0.08 |
| 0:35 | 2nd & 5 | OPP 32 | Brandon Radcliff run for 3 yds to the Clem 29 | +3 | -0.24 |
| 0:08 | 3rd & 2 | OPP 29 | Lamar Jackson pass complete to Cole Hikutini for 28 yds to the Clem 1 for a 1ST down | +28 | 2.27 |
| 0:00 | OPP 0 | End of 1st Quarter | |||
| 14:50 | 1st & 1 | OPP 1 | Lamar Jackson pass incomplete | 0 | -0.96 |
| 14:30 | 2nd & 1 | OPP 1 | Jeremy Smith run for no gain to the Clem 1 | 0 | -0.55 |
| 14:18 | 3rd & 1 | OPP 1 | Jeremy Smith run for 1 yd for a TD, (Blanton Creque KICK) | +1 | 2.45 |
| 14:00 | 1st & 10 | OWN 20 | Wayne Gallman run for 3 yds to the Clem 23 | +3 | -0.24 |
| 13:32 | 2nd & 7 | OWN 23 | Deshaun Watson run for 2 yds to the Clem 25 | +2 | -0.28 |
| 12:56 | 3rd & 5 | OWN 25 | CLEMSON Penalty, False Start (-5 Yards) to the Clem 20 | -5 | |
| 12:29 | 3rd & 10 | OWN 20 | Deshaun Watson pass complete to Jordan Leggett for 24 yds to the Clem 44 for a 1ST down | +24 | 2.84 |
| 12:15 | 1st & 10 | OPP 44 | Deshaun Watson pass complete to Mike Williams for 16 yds to the CLEMSON 40 for a 1ST down LOUISVILLE Penalty, Personal Foul (15 Yards) to the Lvile 25 for a 1ST down | +31 | 0.87 |
| 12:00 | 1st & 10 | OPP 25 | Deshaun Watson pass complete to Trevion Thompson for a loss of 3 yards to the Lvile 28 | -3 | -0.81 |
| 11:30 | 2nd & 13 | OPP 28 | Wayne Gallman run for 13 yds to the Lvile 15 for a 1ST down | +13 | 0.95 |
| 11:12 | 1st & 10 | OPP 15 | Deshaun Watson pass intercepted, touchback. Jaire Alexander return for no gain | -4.44 |
| 10:45 | 1st & 10 | OWN 20 | Lamar Jackson sacked by Albert Huggins for a loss of 7 yards to the Lvile 13 | -7 | -0.89 |
| 10:27 | 2nd & 17 | OWN 13 | Lamar Jackson pass incomplete | 0 | -0.08 |
| 10:00 | 3rd & 17 | OWN 13 | Lamar Jackson run for 5 yds to the Lvile 18 CLEMSON Penalty, Defensive Holding (10 Yards) to the Lvile 28 | +15 | 0.32 |
| 9:45 | 3rd & 2 | OWN 28 | Lamar Jackson run for 9 yds to the Lvile 37 for a 1ST down | +9 | 1.50 |
| 9:26 | 1st & 10 | OWN 37 | Lamar Jackson pass complete to Cole Hikutini for 5 yds to the Lvile 42 | +5 | 0.11 |
| 8:47 | 2nd & 5 | OWN 42 | Lamar Jackson run for 3 yds to the Lvile 45 | +3 | -0.43 |
| 8:33 | 3rd & 2 | OWN 45 | Lamar Jackson pass complete to Cole Hikutini for 6 yds to the Clem 49 for a 1ST down | +6 | 1.61 |
| 8:08 | 1st & 10 | OPP 49 | TEAM run for a loss of 6 yards to the Lvile 45 TEAM fumbled, recovered by Clem | -6 | -2.36 |
| 7:56 | 1st & 10 | OPP 45 | Deshaun Watson pass complete to Artavis Scott for 12 yds to the Lvile 33 for a 1ST down | +12 | 0.57 |
| 7:48 | 1st & 10 | OPP 33 | Deshaun Watson pass complete to Deon Cain for 33 yds for a TD, (Greg Huegel KICK) | +33 | 2.90 |
| 7:32 | 1st & 10 | OWN 25 | Lamar Jackson run for 1 yd to the Lvile 26 | +1 | -0.59 |
| 6:55 | 2nd & 9 | OWN 26 | L.J. Scott run for a loss of 6 yards to the Lvile 20 | -6 | -0.63 |
| 6:37 | 3rd & 15 | OWN 20 | Lamar Jackson pass intercepted Jadar Johnson return for no gain to the Clem 46 | 0.29 |
| 6:27 | 1st & 10 | OWN 46 | Deshaun Watson run for 12 yds to the Lvile 39 Deshaun Watson fumbled, recovered by Lvile , return for a loss of 3 yards to the Lvile 39 | -2.82 |
| 6:20 | 1st & 10 | OWN 39 | Brandon Radcliff run for a loss of 1 yard to the Lvile 38 Brandon Radcliff fumbled, recovered by Clem | -1 | -1.30 |
| 6:15 | 1st & 10 | OPP 38 | LOUISVILLE Penalty, Defensive Pass Interference (14 Yards) to the Lvile 24 for a 1ST down | +14 | |
| 6:09 | 1st & 10 | OPP 24 | Wayne Gallman run for 24 yds for a TD, (Greg Huegel KICK) | +24 | 2.68 |
| 6:09 | 1st & 10 | OWN 25 | LOUISVILLE Penalty, Delay of Game (-5 Yards) to the Lvile 20 | -5 | |
| 5:55 | 1st & 15 | OWN 20 | Jeremy Smith run for 10 yds to the Lvile 30 | +10 | 0.84 |
| 5:34 | 2nd & 5 | OWN 30 | Jeremy Smith run for 3 yds to the Lvile 33 | +3 | -0.31 |
| 4:51 | 3rd & 2 | OWN 33 | Lamar Jackson pass incomplete to Jamari Staples | 0 | -0.60 |
| 4:51 | 4th & 2 | OWN 33 | LOUISVILLE Penalty, Unsportsmanlike Conduct (-15 Yards) to the Lvile 18 | -15 | |
| 4:44 | 4th & 17 | OWN 18 | Mason King punt for 38 yds, fair catch by Ray-Ray McCloud at the Clem 44 |
| 4:31 | 1st & 10 | OWN 44 | Wayne Gallman run for 7 yds to the Lvile 49 | +7 | 0.67 |
| 4:00 | 2nd & 3 | OPP 49 | Deshaun Watson pass complete to Ray-Ray McCloud for 12 yds to the Lvile 37 for a 1ST down | +12 | 0.65 |
| 3:47 | 1st & 10 | OPP 37 | Deshaun Watson pass complete to Deon Cain for 37 yds for a TD, (Greg Huegel KICK) | +37 | 3.05 |
| 3:33 | 1st & 10 | OWN 15 | Lamar Jackson pass complete to James Quick for 8 yds to the Lvile 23 | +8 | 0.69 |
| 3:10 | 2nd & 2 | OWN 23 | L.J. Scott run for 3 yds to the Lvile 26 for a 1ST down | +3 | -0.07 |
| 2:48 | 1st & 10 | OWN 26 | Lamar Jackson pass complete to L.J. Scott for 6 yds to the Lvile 32 | +6 | 0.34 |
| 2:28 | 2nd & 4 | OWN 32 | Lamar Jackson pass complete to Cole Hikutini for 10 yds to the Lvile 42 for a 1ST down | +10 | 1.10 |
| 2:07 | 1st & 10 | OWN 42 | Lamar Jackson pass incomplete to Jamari Staples | 0 | -1.15 |
| 2:02 | 2nd & 10 | OWN 42 | Lamar Jackson pass incomplete to James Quick | 0 | -0.82 |
| 1:51 | 3rd & 10 | OWN 42 | Lamar Jackson run for 10 yds to the Clem 48 for a 1ST down | +10 | 2.85 |
| 1:35 | 1st & 10 | OPP 48 | Lamar Jackson pass complete to James Quick for 25 yds to the Clem 23 for a 1ST down | +25 | 1.02 |
| 1:35 | 1st & 10 | OPP 23 | LOUISVILLE Penalty, Personal Foul (-15 Yards) to the Clem 38 | -15 | |
| 1:25 | 1st & 25 | OPP 38 | Lamar Jackson pass complete to L.J. Scott for 10 yds to the Clem 28 for a 1ST down CLEMSON Penalty, Personal Foul (14 Yards) to the Clem 14 for a 1ST down | +24 | 2.57 |
| 1:23 | 1st & 10 | OPP 14 | Lamar Jackson run for 6 yds to the Clem 8 | +6 | 0.18 |
| 1:20 | 2nd & 4 | OPP 8 | Timeout LOUISVILLE, clock 01:20 | ||
| 0:58 | 2nd & 4 | OPP 8 | Lamar Jackson run for a loss of 1 yard to the Clem 9 | -1 | -0.45 |
| 0:42 | 3rd & 5 | OPP 9 | Lamar Jackson pass incomplete to Cole Hikutini | 0 | -0.35 |
| 0:37 | 4th & 5 | OPP 9 | Blanton Creque 26 yd FG GOOD | -0.83 |
| 0:25 | 1st & 10 | OWN 27 | Deshaun Watson pass complete to Artavis Scott for 23 yds to the 50 yard line for a 1ST down | +23 | 2.09 |
| 0:25 | 1st & 10 | 50 | Timeout CLEMSON, clock 00:25 | ||
| 0:20 | 1st & 10 | 50 | LOUISVILLE Penalty, Defensive Pass Interference (15 Yards) to the Lvile 35 for a 1ST down | +15 | |
| 0:14 | 1st & 10 | OPP 35 | Deshaun Watson pass complete to Mike Williams for 18 yds to the Lvile 17 for a 1ST down | +18 | 0.39 |
| 0:14 | 1st & 10 | OPP 17 | Timeout CLEMSON, clock 00:14 | ||
| 0:09 | 1st & 10 | OPP 17 | Deshaun Watson pass complete to Mike Williams for 12 yds to the Lvile 5 for a 1ST down | +12 | 0.70 |
| 0:05 | 1st & 5 | OPP 5 | Deshaun Watson pass complete to Artavis Scott for 5 yds for a TD, (Greg Huegel KICK) | +5 | 1.88 |
| 0:01 | 1st & 10 | OWN 39 | Lamar Jackson sacked by Clelin Ferrell for a loss of 6 yards to the Lvile 33 | -6 | -1.97 |
| 0:00 | OPP 0 | End of 2nd Quarter |
| 14:45 | 1st & 10 | OWN 27 | Wayne Gallman run for 2 yds to the Clem 29 | +2 | -0.49 |
| 14:21 | 2nd & 8 | OWN 29 | Deshaun Watson pass intercepted Chucky Williams return for no gain to the Clem 36 | -0.58 |
| 14:11 | 1st & 10 | OPP 36 | Lamar Jackson pass complete to James Quick for 2 yds to the Clem 34 | +2 | -0.38 |
| 13:45 | 2nd & 8 | OPP 34 | Lamar Jackson run for 15 yds to the Clem 19 for a 1ST down | +15 | 0.79 |
| 13:25 | 1st & 10 | OPP 19 | Lamar Jackson pass complete to Traveon Samuel for 7 yds to the Clem 12 | +7 | 0.31 |
| 12:55 | 2nd & 3 | OPP 12 | Brandon Radcliff run for 3 yds to the Clem 9 for a 1ST down | +3 | -0.13 |
| 12:28 | 1st & 9 | OPP 9 | Lamar Jackson run for 1 yd to the Clem 8 | +1 | -0.25 |
| 11:55 | 2nd & 8 | OPP 8 | Jeremy Smith run for no gain to the Clem 8 | 0 | -0.27 |
| 11:20 | 3rd & 8 | OPP 8 | Lamar Jackson pass complete to James Quick for 8 yds for a TD, (Blanton Creque PAT BLOCKED) | +8 | 2.95 |
| 11:00 | 1st & 10 | OWN 27 | Wayne Gallman run for 4 yds to the Clem 31 | +4 | -0.12 |
| 10:30 | 2nd & 6 | OWN 31 | Deshaun Watson run for 5 yds to the Clem 36 | +5 | 0.09 |
| 10:00 | 3rd & 1 | OWN 36 | Deshaun Watson run for a loss of 1 yard to the Clem 35 | -1 | -0.87 |
| 9:25 | 4th & 2 | OWN 35 | Andy Teasdall punt for 48 yds , Jaire Alexander returns for 15 yds to the Lvile 32 |
| 9:00 | 1st & 10 | OWN 32 | Lamar Jackson sacked by Albert Huggins for a loss of 3 yards to the Lvile 29 | -3 | -1.29 |
| 8:45 | 2nd & 13 | OWN 29 | CLEMSON Penalty, Defensive Holding (10 Yards) to the Lvile 39 for a 1ST down | +10 | |
| 8:30 | 1st & 10 | OWN 39 | Brandon Radcliff run for 18 yds to the Clem 43 for a 1ST down | +18 | 1.50 |
| 8:15 | 1st & 10 | OPP 43 | Lamar Jackson pass incomplete to Traveon Samuel | 0 | -0.94 |
| 8:04 | 2nd & 10 | OPP 43 | Lamar Jackson pass incomplete to James Quick | 0 | -1.06 |
| 7:50 | 3rd & 10 | OPP 43 | Lamar Jackson pass complete to Cole Hikutini for 20 yds to the Clem 23 for a 1ST down | +20 | 2.69 |
| 7:30 | 1st & 10 | OPP 23 | Lamar Jackson pass incomplete to Jamari Staples | 0 | -0.42 |
| 7:27 | 2nd & 10 | OPP 23 | Lamar Jackson run for 16 yds to the Clem 7 for a 1ST down | +16 | 0.89 |
| 7:12 | 1st & 7 | OPP 7 | Brandon Radcliff run for 1 yd to the Clem 6 | +1 | -0.33 |
| 6:39 | 2nd & 6 | OPP 6 | Lamar Jackson run for 4 yds to the Clem 2 | +4 | -0.02 |
| 6:07 | 3rd & goal | OPP 2 | Timeout LOUISVILLE, clock 06:07 | ||
| 5:50 | 3rd & 2 | OPP 2 | Lamar Jackson run for a loss of 3 yards to the Clem 5 | -3 | -0.51 |
| 5:21 | 4th & 5 | OPP 5 | Blanton Creque 21 yd FG GOOD | -0.95 |
| 4:50 | 1st & 10 | OWN 25 | Wayne Gallman run for 4 yds to the Clem 29 | +4 | -0.11 |
| 4:43 | 2nd & 6 | OWN 29 | Deshaun Watson pass incomplete to Artavis Scott | 0 | -0.65 |
| 4:34 | 3rd & 6 | OWN 29 | Deshaun Watson run for 23 yds to the Lvile 48 for a 1ST down | +23 | 3.16 |
| 4:18 | 1st & 10 | OPP 48 | Wayne Gallman run for 6 yds to the Lvile 42 | +6 | 0.33 |
| 4:00 | 2nd & 4 | OPP 42 | Deshaun Watson pass complete to Deon Cain for 4 yds to the Lvile 38 for a 1ST down | +4 | 0.26 |
| 3:49 | 1st & 10 | OPP 38 | Deshaun Watson run for 18 yds to the Lvile 20 for a 1ST down | +18 | 0.48 |
| 3:27 | 1st & 10 | OPP 20 | Deshaun Watson pass complete to Jordan Leggett for 15 yds Jordan Leggett fumbled, recovered by Lvile , return for 18 yds to the Lvile 23 | -4.38 |
| 3:00 | 1st & 10 | OWN 23 | Brandon Radcliff run for 11 yds to the Lvile 34 for a 1ST down | +11 | 0.87 |
| 2:30 | 1st & 10 | OWN 34 | Brandon Radcliff run for 2 yds to the Lvile 36 | +2 | -0.62 |
| 2:00 | 2nd & 8 | OWN 36 | Brandon Radcliff run for 1 yd to the Lvile 37 | +1 | -0.62 |
| 1:35 | 3rd & 7 | OWN 37 | Lamar Jackson pass complete to Jeremy Smith for 29 yds to the Clem 34 for a 1ST down | +29 | 3.63 |
| 1:22 | 1st & 10 | OPP 34 | Lamar Jackson pass complete to James Quick for 22 yds to the Clem 12 for a 1ST down | +22 | 0.41 |
| 0:59 | 1st & 10 | OPP 12 | Lamar Jackson run for 11 yds to the Clem 1 for a 1ST down | +11 | 1.59 |
| 0:45 | 1st & 1 | OPP 1 | Lamar Jackson run for 1 yd for a TD, (Blanton Creque KICK) | +1 | 0.94 |
| 0:31 | 1st & 10 | OWN 24 | Wayne Gallman run for 11 yds to the Clem 35 for a 1ST down | +11 | 0.90 |
| 0:10 | 1st & 10 | OWN 35 | Deshaun Watson pass complete to Ray-Ray McCloud for 3 yds to the Clem 38 | +3 | -0.41 |
| 0:00 | OWN 0 | End of 3rd Quarter | |||
| 14:45 | 2nd & 7 | OWN 38 | Wayne Gallman run for no gain to the Clem 38 | 0 | -0.87 |
| 14:14 | 3rd & 7 | OWN 38 | Deshaun Watson pass incomplete | 0 | -0.48 |
| 14:05 | 4th & 7 | OWN 38 | Andy Teasdall punt for 36 yds , Jaire Alexander returns for no gain to the Lvile 26 Jaire Alexander fumbled, recovered by Lvile |
| 13:55 | 1st & 10 | OWN 26 | Lamar Jackson run for 3 yds to the Lvile 29 | +3 | -0.31 |
| 13:22 | 2nd & 7 | OWN 29 | Lamar Jackson pass complete to Cole Hikutini for 12 yds to the Lvile 41 for a 1ST down | +12 | 1.66 |
| 12:58 | 1st & 10 | OWN 41 | Lamar Jackson pass complete to Jaylen Smith for 7 yds to the Lvile 48 | +7 | 0.70 |
| 12:36 | 2nd & 3 | OWN 48 | Lamar Jackson run for 22 yds to the Clem 30 for a 1ST down | +22 | 1.15 |
| 12:08 | 1st & 10 | OPP 30 | CLEMSON Penalty, Defensive Holding (10 Yards) to the Clem 20 for a 1ST down | +10 | |
| 12:08 | 1st & 10 | OPP 20 | LOUISVILLE Penalty, False Start (-5 Yards) to the Clem 25 | -5 | |
| 11:56 | 1st & 15 | OPP 25 | Lamar Jackson run for a loss of 6 yards to the Clem 31 | -6 | -1.44 |
| 11:30 | 2nd & 21 | OPP 31 | Lamar Jackson pass complete to Jeremy Smith for 9 yds to the Clem 22 | +9 | 0.74 |
| 11:00 | 3rd & 12 | OPP 22 | Lamar Jackson pass complete to Jamari Staples for 10 yds to the Clem 12 | +10 | 0.64 |
| 10:23 | 4th & 2 | OPP 12 | Blanton Creque 28 yd FG GOOD | -0.90 |
| 10:00 | 1st & 10 | OWN 31 | Wayne Gallman run for 1 yd to the Clem 32 | +1 | -0.74 |
| 9:41 | 2nd & 9 | OWN 32 | Deshaun Watson pass intercepted Jaire Alexander return for no gain to the Lvile 44 | -0.65 |
| 9:20 | 1st & 10 | OWN 44 | Lamar Jackson run for 38 yds to the Clem 18 for a 1ST down | +38 | 1.78 |
| 8:30 | 1st & 10 | OPP 18 | Brandon Radcliff run for 5 yds to the Clem 13 | +5 | 0.07 |
| 8:10 | 2nd & 5 | OPP 13 | Lamar Jackson run for 2 yds to the Clem 11 | +2 | -0.21 |
| 7:52 | 3rd & 3 | OPP 11 | Lamar Jackson run for 11 yds for a TD, (Blanton Creque KICK) | +11 | 2.73 |
| 7:29 | 1st & 10 | OPP 23 | Deshaun Watson run for 3 yds to the Lvile 20 | +3 | -0.13 |
| 7:05 | 2nd & 7 | OPP 20 | Deshaun Watson pass complete to Mike Williams for 20 yds for a TD, (Deshaun Watson intercepted ) | +20 | 2.79 |
| 6:55 | 1st & 10 | OWN 29 | Lamar Jackson pass incomplete | 0 | -0.83 |
| 6:30 | 2nd & 10 | OWN 29 | Lamar Jackson pass complete to Jeremy Smith for 7 yds to the Lvile 36 | +7 | 0.37 |
| 6:19 | 3rd & 3 | OWN 36 | Lamar Jackson pass incomplete to Cole Hikutini | 0 | -0.62 |
| 6:11 | 4th & 3 | OWN 36 | Mason King punt for 49 yds, fair catch by Ray-Ray McCloud at the Clem 15 |
| 6:00 | 1st & 10 | OWN 15 | Wayne Gallman run for 6 yds to the Clem 21 | +6 | 0.25 |
| 5:40 | 2nd & 4 | OWN 21 | Deshaun Watson pass complete to Mike Williams for 4 yds to the Clem 25 for a 1ST down | +4 | 0.30 |
| 5:20 | 1st & 10 | OWN 25 | Deshaun Watson pass incomplete to Artavis Scott | 0 | -0.70 |
| 5:10 | 2nd & 10 | OWN 25 | Deshaun Watson pass complete to Trevion Thompson for 15 yds to the Clem 40 for a 1ST down | +15 | 2.02 |
| 4:45 | 1st & 10 | OWN 40 | Wayne Gallman run for 3 yds to the Clem 43 | +3 | -0.43 |
| 4:22 | 2nd & 7 | OWN 43 | Deshaun Watson run for 2 yds to the Clem 45 | +2 | -0.63 |
| 3:48 | 3rd & 5 | OWN 45 | Deshaun Watson pass complete to Deon Cain for 24 yds to the Lvile 31 for a 1ST down | +24 | 2.97 |
| 3:14 | 1st & 10 | OPP 31 | Deshaun Watson pass complete to Jordan Leggett for 31 yds for a TD, (Deshaun Watson pass to Jordan Leggett for Two-Point Conversion) | +31 | 2.84 |
| 3:08 | 1st & 10 | OWN 25 | Lamar Jackson pass complete to Jamari Staples for 12 yds to the Lvile 37 for a 1ST down | +12 | 1.03 |
| 2:40 | 1st & 10 | OWN 37 | Lamar Jackson run for 8 yds to the Lvile 45 | +8 | 1.04 |
| 2:12 | 2nd & 2 | OWN 45 | Lamar Jackson pass complete to Cole Hikutini for 3 yds to the Lvile 48 for a 1ST down | +3 | 0.01 |
| 1:54 | 1st & 10 | OWN 48 | Lamar Jackson pass complete to Jeremy Smith for 9 yds to the Clem 43 | +9 | 1.15 |
| 1:48 | 2nd & 1 | OPP 43 | Lamar Jackson run for 15 yds to the Clem 28 for a 1ST down | +15 | 0.09 |
| 1:32 | 1st & 10 | OPP 28 | Lamar Jackson pass complete to James Quick for 7 yds to the Clem 21 | +7 | 0.34 |
| 1:27 | 2nd & 3 | OPP 21 | Lamar Jackson pass complete to Reggie Bonnafon for 9 yds to the Clem 12 for a 1ST down | +9 | -0.11 |
| 1:27 | 1st & 10 | OPP 12 | Timeout CLEMSON, clock 01:27 | ||
| 1:19 | 1st & 10 | OPP 12 | Jeremy Smith run for 3 yds to the Clem 9 | +3 | -0.10 |
| 0:48 | 2nd & 7 | OPP 9 | Lamar Jackson run for no gain to the Clem 9 | 0 | -0.30 |
| 0:40 | 3rd & 7 | OPP 9 | Lamar Jackson pass incomplete to Cole Hikutini | 0 | -0.36 |
| 0:40 | 4th & 7 | OPP 9 | Timeout LOUISVILLE, clock 00:40 | ||
| 0:40 | 4th & 7 | OPP 9 | LOUISVILLE Penalty, False Start (-5 Yards) to the Clem 14 | -5 | |
| 0:33 | 4th & 12 | OPP 14 | Lamar Jackson pass complete to James Quick for 11 yds to the Clem 3 | +11 | -3.08 |
| 0:33 | 1st & 10 | OWN 3 | Timeout LOUISVILLE, clock 00:33 | ||
| 0:05 | 1st & 10 | OWN 3 | TEAM run for no gain to the Clem 3 | 0 | -0.26 |
| 0:00 | OWN 0 | End of 4th Quarter |
| 0 | sacks | 5 |
| 2 | plays for loss | 12 |
| 6 | takeaways | 3 |
| 2 | three-and-outs forced | 4 |
| 14 | explosive plays allowed | 16 |
| 8.25 | yards allowed / play | 5.98 |
| 6 of 17 | scoring drives allowed | 7 of 17 |
| Josh Harvey-Clemons | 11 (6) | |
| Zykiesis Cannon | 8 (3) | 1 TFL |
| Chucky Williams | 7 (5) | 1 INT |
| Keith Kelsey | 7 (4) | |
| James Hearns | 5 (5) | 1 TFL · 1 PD |
| Stacy Thomas | 4 (2) | |
| Drew Bailey | 3 (3) | |
| Lamar Atkins | 3 (2) |
| Ben Boulware | 18 (8) | 1 sk · 3 TFL · 1 PD |
| Van Smith | 16 (13) | |
| Marcus Edmond | 11 (8) | |
| Jadar Johnson | 7 (4) | 1 INT · 1 PD |
| Kendall Joseph | 7 (4) | 2 QH |
| Dexter Lawrence | 7 | 2 QH |
| Clelin Ferrell | 6 (2) | 2 sk · 2 TFL · 1 QH |
| Christian Wilkins | 5 (2) | 1.5 TFL · 1 PD · 2 QH |
| 3 of 3 | field goals | — |
| 5 | punts | 5 |
| 48.0 | punt average | 42.8 |
| 0 | punts inside the 20 | 0 |
| 61 | return yards | 216 |
| own 22 | average drive start | own 31 |
| K | Blanton Creque | 3/3 FG · long 28 · 3/4 XP |
| P | Mason King | 5 punts · 48.0 avg |
| KR | Traveon Samuel | 2 ret · 32 yds · long 17 |
| KR | Jaire Alexander | 1 ret · 14 yds · long 14 |
| PR | Jaire Alexander | 2 ret · 15 yds · long 15 |
| K | Greg Huegel | 4/4 XP |
| P | Andy Teasdall | 5 punts · 42.8 avg |
| KR | Artavis Scott | 3 ret · 119 yds · long 77 |
| KR | Tavien Feaster | 5 ret · 98 yds · long 21 |
| PR | Ray-Ray McCloud | 2 ret · -1 yds |
| 99 | plays | 60 |
| 592 | yards | 495 |
| 17 | drives | 16 |
| 47% | success rate | 50% |
| 22.59 | total PPA | 20.43 |
| Q2 | Jeremy Smith run for 1 yd for a TD, (Blanton Creque KICK) | 7–0 |
| Q2 | Deshaun Watson pass complete to Deon Cain for 33 yds for a TD, (Greg Huegel KICK) | 7–7 |
| Q2 | Wayne Gallman run for 24 yds for a TD, (Greg Huegel KICK) | 14–7 |
| Q2 | Deshaun Watson pass complete to Deon Cain for 37 yds for a TD, (Greg Huegel KICK) | 21–7 |
| Q2 | Blanton Creque 26 yd FG GOOD | 10–21 |
| Q2 | Deshaun Watson pass complete to Artavis Scott for 5 yds for a TD, (Greg Huegel KICK) | 28–10 |
| Q3 | Lamar Jackson pass complete to James Quick for 8 yds for a TD, (Blanton Creque PAT BLOCKED) | 16–28 |
| Q3 | Blanton Creque 21 yd FG GOOD | 19–28 |
| Q3 | Lamar Jackson run for 1 yd for a TD, (Blanton Creque KICK) | 26–28 |
| Q4 | Blanton Creque 28 yd FG GOOD | 29–28 |
| Q4 | Lamar Jackson run for 11 yds for a TD, (Blanton Creque KICK) | 36–28 |
| Q4 | Deshaun Watson pass complete to Mike Williams for 20 yds for a TD, (Deshaun Watson intercepted ) | 34–36 |
| Q4 | Deshaun Watson pass complete to Jordan Leggett for 31 yds for a TD, (Deshaun Watson pass toβ¦ | 42–36 |
| Q3 | Lamar Jackson pass complete to Jeremy Smith for 29 yds to the Clem 34 for a 1ST down | 3.63 |
| Q3 | Deshaun Watson run for 23 yds to the Lvile 48 for a 1ST down | 3.16 |
| Q2 | Deshaun Watson pass complete to Deon Cain for 37 yds for a TD, (Greg Huegel KICK) | 3.05 |
| Q4 | Deshaun Watson pass complete to Deon Cain for 24 yds to the Lvile 31 for a 1ST down | 2.97 |
| Q3 | Lamar Jackson pass complete to James Quick for 8 yds for a TD, (Blanton Creque PAT⦠| 2.95 |
| Q2 | Deshaun Watson pass complete to Deon Cain for 33 yds for a TD, (Greg Huegel KICK) | 2.90 |
| 2025 | Clemson 20 – 19 Louisville |
| 2024 | Louisville 33 – 21 Clemson |
| 2022 | Louisville 16 – 31 Clemson |
| 2021 | Clemson 30 – 24 Louisville |
| 2019 | Clemson 45 – 10 Louisville |
| 2018 | Louisville 16 – 77 Clemson |
| 2017 | Clemson 47 – 21 Louisville |
| 2015 | Clemson 20 – 17 Louisville |